HIV Reverse Transcriptase and its Inhibitors



Didanosine

What Is Didanosine?

Didanosine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Didanosine is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).Didanosine is not a cure for HIV or AIDS.

Didanosine is for use in adults and children who are at least 2 weeks old.

Didanosine may also be used for purposes not listed in this medication guide.

Do not take didanosine together with allopurinol, ribavirin, or stavudine.

You may developlactic acidosis,a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

This medicine can also cause severe or life-threatening effects on your liver or pancreas.Call your doctor at once if you have: severe pain in your upper stomach (may spread to your back), nausea and vomiting, fast heart rate, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

You should not use didanosine if you are allergic to it.Do not take didanosine together with allopurinol, ribavirin, or stavudine.

Tell your doctor if you have ever had:

  • liver disease or pancreatitis (didanosine can cause severe or life-threatening effects on your liver or pancreas);
  • kidney disease (or if you are on dialysis);
  • numbness or tingling in your hands or feet, including Raynaud's syndrome; or
  • if you drink large amounts of alcohol.

You may developlactic acidosis,a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

If you are pregnant, do not take didanosine together with stavudine.This combination can be very dangerous during pregnancy.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Didanosine Side Effects

Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

  • numbness, tingling, or pain in your hands or feet;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • vision changes; or
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Didanosine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;
  • rash;
  • headache; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Didanosine Interactions

Didanosine Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take didanosine on an empty stomach, at least 30 minutes before or 2 hours after a meal. Do not take with food.

Shake theoral suspension(liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Swallow the capsule whole and do not crush, chew, break, or open it.

HIV/AIDS is usually treated with a combination of drugs, but certain HIV medications or antibiotics should not be taken at the same time as didanosine.These other medicines can affect the levels of didanosine in your blood stream:

  • Ciprofloxacin should be taken at least 2 hours before or 6 hours after you take didanosine.
  • Delavirdine or indinavir should be taken at least 1 hour before you take didanosine.
  • Nelfinavir should be taken at least 1 hour after you take didanosine.
  • Itraconazole or ketoconazole should be taken at least 2 hours before you take didanosine.

Use all HIV medications as directed and read all medication guides you receive.Do not change your dose or dosing schedule without your doctor's advice.Every person with HIV should remain under the care of a doctor.

You will need frequent medical tests. Your vision may also need to be checked.

Store thetabletsorcapsulesat room temperature in a tightly closed container, away from moisture and heat.

Store theliquidin the refrigerator. Throw away any leftover didanosine liquid that is more than 30 days old.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.Do nottake two doses at one time.

Copyright 1996-2019 Cerner Multum, Inc.






Video: HIV: Mechanisms of Action of Protease Inhibitors (PIs)

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Date: 06.12.2018, 15:07 / Views: 45535